Illuminating Personalized Medicine

Illuminating Personalized Medicine

Illuminating Personalized Medicine

Porphyrin-based Aggregation-induced Emission Generating Molecules for Continuous Multi-Metabolite Monitoring

Personialized Medicine Study

In this project, a new sensor technology is being developed to improve the monitoring of multiple metabolites. Special molecules with aggregation-induced emission, known as AIEgens, are utilized, which emit particularly bright luminescence upon aggregation. These AIEgens are designed to emit light in different spectral regions, enabling the simultaneous measurement of various metabolites such as glucose, lactate, and ketones. Integrated into a biocompatible matrix and applied to the tip of an optical sensor, which is incorporated into a wearable device, this minimally invasive system allows for continuous monitoring of metabolism in the interstitial fluid under the skin. This technology has the potential to significantly improve diagnosis and personalized treatment for conditions like diabetes and cardiovascular diseases.

Project team: Prof. Lilian Witthauer, Dr. Emmanouil Rousakis

Funding: Swiss National Science Foundation

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* Pflichtfelder
DSGVO *

DCB Research AG

Freiburgstrasse 3
3010 Bern
Switzerland

Volatile Organic Compounds in Breath

Volatile Organic Compounds in Breath

Volatile Organic Compounds in Breath

Volatile organic compounds and breath analysis in people with diabetes

Breath analysis in individuals with diabetes

The main goal of this research area is to identify distinctive patterns of Volatile Organic Compounds (VOCs)s in breath and their dependence on blood glucose values in individuals with diabetes. VOCs are emitted by the human body, among which breath is the most important carrier. The breath contains a diverse array of VOCs that offer valuable insights into the body’s metabolic activities, including the glucose metabolism.

Project team: Prof. Lilian Witthauer, Prof. Markus Laimer

Funding: Diabetes Center Berne, University of Bern

Publications:
Nicolier C, Künzler J, Lizoain A, et al. Detection of hypoglycaemia in type 1 diabetes through breath volatile organic compound profiling using gas chromatography–ion mobility spectrometry. Diabetes Obes Metab. 2024; 1-8. doi:10.1111/dom.15944

More recent projects

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* Pflichtfelder
DSGVO *

DCB Research AG

Freiburgstrasse 3
3010 Bern
Switzerland