DCB Newsletter #4/23: INSIDE DCB – Interview with Prof. Lilian Witthauer

DCB Newsletter #4/23: INSIDE DCB – Interview with Prof. Lilian Witthauer

Dear Community,

We’re thrilled to present you with the next episode or our series „INSIDE DCB“ – this time, an interview with Prof. Lilian Witthauer. Enjoy the read!

Since 2021, Lilian Witthauer has been a professor specialising in sensor technology at the University Department of Diabetology, Endocrinology, Nutritional Medicine and Metabolism (UDEM) and at the DCB (Diabetes Center Berne). Together with her team, she researches innovative sensor technologies to improve the daily lives of people with diabetes.

Lilian, what is your research about?

My field of research is very interdisciplinary and includes both the scientific fundamentals of sensor technology and the clinical aspects of diabetes research. In particular, I focus on the development and improvement of sensors that enable people with diabetes to continuously measure blood glucose levels. An important aspect of my work is to make these sensors more accurate and reliable to enable automated insulin delivery. To achieve this goal, we redesign sensors, use different materials and optimise insulin delivery.

What motivates you to work in the field of diabetes technology? How did you get into it as a physicist?

What motivates me most is that people with diabetes can live better lives by having access to advanced sensor technologies that improve their healthcare and promote self-control and responsibility. I am involved in the field of diabetes technology as a physicist because I have always been interested in the application of physical principles and methods in medicine. As part of a changing society, diabetes is an important topic where there are still many opportunities for development.

What is your biggest challenge as a professor?

My biggest challenge as a professor is to find a balance between research, teaching and administration and to ensure that my team and I achieve our goals effectively and efficiently. This is not always easy, as I only have a short time for each individual task. It’s like I’m strategically managing a company, and at the same time I’m responsible for the operational implementation, while also taking care of the finances and IT.

Professor Dr. Lilian Witthauer. Assistant Professor with Tenure Track in Diabetes Technology. Photo credit: Sandra Blaser

What goals do you want to achieve with your team and your laboratory, the samlab (Sensing and Monitoring Lab)?

In collaboration with my team and samlab, I am pursuing the goal of developing innovative sensor technologies that make everyday life easier for people with diabetes and improve their quality of life. In addition, we want to promote interdisciplinarity and closely link our research results with practice.

What projects are you currently researching and how can they make life easier for people with diabetes?

One of my current projects deals with the development of a sensor that measures the glucose level in the blood continuously and without delay. The instantaneous measurement is of special interest when the blood glucose level changes rapidly, during meals, sports, or stress. The glucose sensor is based on a light-based measurement method and therefore differs from existing sensors on the market.

Such a sensor could be worn longer and would allow for completely automated insulin delivery. This would reduce the number of decisions a person with diabetes has to make every day and thus improve the quality of life.

How do you work with the DCB?

The DCB offers a unique environment where I work closely with project managers and experts from the hospital, statistics and business environment. We have regular meetings and interdisciplinary working groups to coordinate our work and drive the development of innovative solutions. In addition, the DCB connects me with industry partners and start-ups, which is very important in my research field.

Where do you hope your research field will be in 5-10 years? What is your vision?

My vision is that in 5-10 years, a wide range of innovative sensor technologies will be available to make the daily lives of people with diabetes easier and improve their healthcare.

I hope that our research will help to make monitoring blood glucose levels easier and more accurate, and that people with diabetes will be able to make better decisions about their diet, exercise and insulin therapy based on real-time data.

About Lilian Witthauer

Lilian Witthauer is Assistant Professor of Diabetes Technology at the University of Bern and the Diabetes Center Berne (DCB). She studied physics in Basel, completed a Master of Advanced Studies in medical physics at ETH Zurich and graduated with a PhD in nuclear and particle physics from the University of Basel in 2015. Lilian Witthauer has done postdoctoral research in the development of optical sensors for navigation during surgery at the Department of Biomedical Engineering at the University of Basel and on oxygen sensors at Massachusetts General Hospital and Harvard Medical School in Boston (USA).

More about samlab: https://samlab.org

Dieser Beitrag wurde zuerst als Newsletter auf LinkedIn publiziert. Klicke hier um den Artikel auf LinkedIn zu lesen.

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DCB unterstützt T1D1 – eine App des jüngsten Teilnehmers der Open Innovation Challenge

DCB unterstützt T1D1 – eine App des jüngsten Teilnehmers der Open Innovation Challenge

DCB unterstützt T1D1 – eine App des jüngsten Teilnehmers der Open Innovation Challenge

Bern und Washington D.C. – Das DCB gab heute eine Zusammenarbeit mit T1D1 (Type 1 From Day 1), einer App des Teenagers Drew Mendelow, bekannt. Nach seiner Diagnose mit Typ 1 Diabetes im Jahr 2020 hat der heute 16-Jährige eine App zur Vereinfachung von Diabetesmanagements vom ersten Tag der Diagnose an entwickelt. Das DCB wird das Projekt mit Know-How und finanziellen Mitteln unterstützen, um die erforderlichen Unterlagen zu erstellen, die für die Zulassung der T1D1-App bei der FDA (USA) und bei der Europäischen Union im Rahmen der Medizinprodukteverordnung (MDR) nötig sind.

Die App hat derzeit über 45.0000 Downloads, vor allem in den USA. Die Zulassung ist für die weitere Nutzung der App erforderlich, und um in Zukunft mehr Menschen mit Diabetes eine adäquate App-Lösung anbieten zu können, sowohl in Europa als auch in den USA.

„Wir vom DCB freuen uns, dass wir einem Teenager helfen können, seine Lösung auf dem Markt zu halten – eine Lösung von einem Menschen, der mit Diabetes lebt, für Menschen mit den gleichen Bedürfnissen“, sagt Derek Brandt, CEO des Diabetes Center Berne.

Siehe auch https://www.fox5dc.com/news/13-year-old-designs-app-to-help-children-battling-chronic-conditionandund hören dir die großartige Geschichte von Drew und seiner Reise an!

Drew Mendelow (Gründer von T1D1) an der DCB Start-Up Night 2023

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DCB Newsletter #3/23: DID YOU KNOW… the risk factors for women’s health in diabetes?

DCB Newsletter #3/23: DID YOU KNOW… the risk factors for women’s health in diabetes?

DCB Newsletter #3/23: DID YOU KNOW… the risk factors for women’s health in diabetes?

Dear Community,

We’re thrilled to present you with the next episode of our series “DID YOU KNOW” where we present medical facts around diabetes that you might not know yet. Enjoy the read and thank you Dr. Stefanie Hofer for being our author on International Women’s Day!

1. Cardiovascular mortality

Managing diabetes is a daily struggle but is poses even greater risks and challenges for women. Generally, diabetes roughly doubles the risk for cardiovascular mortality, for women it is even a three-fold risk-increase. They are likely to have earlier heart attacks and are more likely to die from it.1 Due to differences in acute symptoms, women often don’t get the right treatment for severe cardiac events: While men may present with excruciating chest pain, women often display less obvious symptoms like neck- and abdominal pain, insomnia, and shortness of breath.

2. Reproductive health

Women with diabetes also face additional challenges related to their reproductive health. Conditions such as Polycystic Ovary Syndrome (PCOS), hormonal imbalances, impaired fertility, aggravation of menopausal symptoms and urinary tract infections (UTIs) occur all too frequently and can be a significant limitation in daily life.

3. Mental burden

Besides physical problems, the mental burden of diabetes weighs heavy. Stigma around weight and lifestyle in diabetes is highly prevalent and affects women more often than men. In gestational diabetes, women may experience stigma in the form of discrimination from health personnel, guilt and shame. While weight and lifestyle are important risk factors, gestational diabetes also occurs in metabolically healthy women, and these feelings of blame can be a heavy burden during this time.

4. Being criticised

Women also are more likely to feel criticized for their dietary choices and body weight, both in the media and personally. The recommendation to „just move more and eat better “, or questions such as „are you really allowed to eat that?“, can take on special significance in women. The constant preoccupation with food, weighing it, reading labels, rating its nutritional value, and classifying it into „good“ and „bad“ can be a major contributor to an unhealthy relationship with food. In female adolescents, eating disorders and weight dysphoria are particularly common and even more so in females with type 1 diabetes.

5. Sex disparities

It begins early on: a recent published systematic review showed that girls with T1D have higher BMIs, worse glycemic control, need higher insulin doses, more hospitalisations, and a lower quality of life, compared to their male counterparts.

So, what is needed to improve women’s health care in diabetes? One step is raising awareness and fostering understanding. But more than understanding, women and girls with diabetes need special attention from their physicians to their unique concerns: their physical symptoms, their mental health, and secure access to a tight support-network from various fields of health care.

Thanks so much for reading and we’ll provide you with the next episode of this series soon!

Norhammar A. Diabetes and cardiovascular mortality: the impact of sex. Lancet Diabetes Endocrinol. 2018 Jul;6(7):517-519. doi: 10.1016/S2213-8587(18)30111-6. Epub 2018 May 8. Erratum in: Lancet Diabetes Endocrinol. 2018 Jul;6(7):e6. PMID: 29752193.

Keteepe-Arachi T, Sharma S. Cardiovascular Disease in Women: Understanding Symptoms and Risk Factors. Eur Cardiol. 2017 Aug;12(1):10-13. doi: 10.15420/ecr.2016:32:1. PMID: 30416543; PMCID: PMC6206467.

Davidsen E, Maindal HT, Rod MH, Olesen K, Byrne M, Damm P, Nielsen KK. The stigma associated with gestational diabetes mellitus: A scoping review. EClinicalMedicine. 2022 Aug 11;52:101614. doi: 10.1016/j.eclinm.2022.101614. PMID: 35990581; PMCID: PMC9386490.

Striegel-Moore RH, Rosselli F, Perrin N, DeBar L, Wilson GT, May A, Kraemer HC. Gender difference in the prevalence of eating disorder symptoms. Int J Eat Disord. 2009 Jul;42(5):471-4. doi: 10.1002/eat.20625. PMID: 19107833; PMCID: PMC2696560.

de Vries, Silvia & Verheugt, Carianne & Mul, Dick & Nieuwdorp, Max & Sas, Theo. (2023). Do sex differences in paediatric type 1 diabetes care exist? A systematic review. Diabetologia. 66. 10.1007/s00125-022-05866-4.

Dieser Beitrag wurde zuerst als Newsletter auf LinkedIn publiziert. Klicke hier um den Artikel auf LinkedIn zu lesen.

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DCB Newsletter #2/23: INSIDE DCB – our Research Facility

DCB Newsletter #2/23: INSIDE DCB – our Research Facility

DCB Newsletter #2/23: INSIDE DCB – our Research Facility

Do you already know all the services of DCB? With our Service Portfolio, DCB accompanies you on your entire translational journey. Would you like to conduct a study or research, but lack the appropriate premises and services? You might want to check out our research facility. Thanks to Thomas Gerber for the contribution!

The DCB Research Facility is located in the sitem-insel building on the 4th floor in Bern, Switzerland.

On more than 700 m2 the facility offers space for office workstations and project rooms. It was designed in such a way that each room can be adapted highly flexibly to the corresponding requirements of each project. Today it can be an office, tomorrow it is already a laboratory.

At the moment, DCB has three units in operation:

The Clinic offers space for clinical trials including the possibility for studies with overnight stays for up to 6 participants. The facilities have been designed to perform Diabetes Technology trials for new Glucose Sensors (BGM, CGM), Closed-Loop Trials and even Clamp Studies can be performed here:

The Metabolic Research Lab meets the requirements of Biological Safety Level Lab:

The third unit has been set up for our first professorship and provides space for optical experiments in a Biological Safety Level 1 hygienic area.

Each unit has its own equipment with maintenance and calibration interval; adapted to the applicable regulations.

Controlled storage conditions are also provided so that the respective sample material and the necessary materials can be adequately stored.

Are you interested in carrying out your studies or projects in a safe and controlled environment and benefit from the numerous services offered by our teams? Learn more about it here and contact us.

Thanks for reading, dear community, and till next time!

Dieser Beitrag wurde zuerst als Newsletter auf LinkedIn publiziert. Klicke hier um den Artikel auf LinkedIn zu lesen.

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Freiburgstrasse 3
3010 Bern
Switzerland